![]() ![]() Systematic Reviews are critical assessments of the literature and data sources pertaining to clinical topics, emphasizing factors such as cause, diagnosis, prognosis, therapy, or prevention. Systematic Review (without meta-analysis) Letters not meeting these specifications are generally not considered. They should not include an abstract or key points, but otherwise should follow all of the guidelines in Manuscript Preparation and Submission Requirements. In general, Research Letters should be divided into the following sections: Introduction, Methods, Results, and Discussion. Letters must not duplicate other material published or submitted for publication. Other persons who have contributed to the study may be indicated in an Acknowledgment, with their permission, including their academic degrees, affiliation, contribution to the study, and an indication if compensation was received for their role. The text should include the full name, academic degrees, and a single institutional affiliation for each author and the email address for the corresponding author. Research Letters may have no more than 7 authors. Online supplementary material is only allowed for brief additional and absolutely necessary methods but not for any additional results or discussion. These should not exceed 600 words of text and 6 references and may include up to 2 tables or figures. Research Letters are concise, focused reports of original research. Maximum length: 3000 words of text (not including abstract, tables, figures, acknowledgments, references, and online-only material) with no more than a total of 5 tables and/or figures. A list of 3 Key Points is required (see guidance on preparing Key Points). Follow EQUATOR Reporting Guidelines.Ī structured abstract is required for more information, see instructions for preparing Abstracts for Reports of Original Data. Data included in research reports must be original and should be as timely and current as possible (see Timeliness of Data). Each manuscript should clearly state an objective or hypothesis the design and methods (including the study type and setting and dates, patients or participants with inclusion and exclusion criteria and/or participation or response rates, or data sources, and how these were selected for the study) the essential features of any interventions the main outcome measures the main results of the study a discussion section placing the results in context with the published literature and addressing study limitations and the conclusions and relevant implications for clinical practice or health policy. These reports typically include randomized trials (see Clinical Trial), intervention studies, cohort studies, case-control studies, epidemiologic assessments, other observational studies, surveys with high response rates (see Reports of Survey Research), cost-effectiveness analyses and decision analyses (see Reports of Cost-effectiveness Analyses and Decision Analyses), and studies of screening and diagnostic tests (see also Reports of Diagnostic Tests). Decisions and Management of Editorial Conflicts of Interest.Personal Communications and Unpublished Data.Ethical Approval of Studies and Informed Consent.Reporting Demographic Information for Study Participants.Data Access, Responsibility, and Analysis.Funding/Support and Role of Funder/Sponsor.Conflicts of Interest and Financial Disclosures.Research Article Public Access, Depositing in Repositories, and Discoverability.Previous or Planned Meeting Presentation or Release of Information.Previous Publication, Related Manuscripts and Reports, and Preprints.About Previous Release of Information, Embargo, and Access.Authorship Form and Publishing Agreement.Statistical Methods and Data Presentation.Gene Names, Symbols, and Accession Numbers. ![]() ![]() Names of Drugs, Devices, and Other Products.Copies of Previous Editorial and Reviewer Comments.Manuscript Preparation and Submission Requirements. ![]()
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